Reduce the bad LDL

Your body, mainly your liver, produces 75 percent of your cholesterol. Your small intestine also aids in both the creation and absorption of cholesterol [source: AHA]. The average diet adds another 300 to 500 mg of cholesterol [source: Schafer]. This external cholesterol comes from animal and dairy products. But even if you eat foods without cholesterol, the carbs, fats and proteins all break down eventually and release carbon, which your liver turns into cholesterol.

As you age, plaque tends to build up in the lining of your arteries. Some of those fatty deposits may be made of excess LDL This plaque buildup can result in the arteries hardening and narrowing at the site of the blockages, a condition called atherosclerosis.

In addition to leptin, the other important hormone made by your fat is adiponectin.

α-linolenic in sunflower seeds, flaxseeds, walnuts, almonds, peanuts, cashews, pecans and walnuts are all excellent sources of heart-healthy oils for raising HDL levels.
palm oil, and coconut oil
If you see partially hydrogenated fat in the Ingredient watch out for trans fats.

List of a food label, that food has trans fats.

The Five Rules of the The Leptin Diet:
Rule 1:  Never eat after dinner.
Rule 2:  Eat three meals a day. 
Rule 3:  Do not eat large meals. 
Rule 4:  Eat a breakfast containing protein.
Rule 5:  Reduce the amount of carbohydrates eaten.